论文部分内容阅读
目的:探讨转化生长因子α(TGF-α)与表皮生长因子受体(EGFR)在继发性甲状旁腺功能亢进症(SHPT)患者甲状旁腺腺体组织中的表达及意义。方法:收集36例SHPT组织标本以及7例正常甲状旁腺组织标本,HE染色区分弥漫性增生和结节性增生甲状旁腺,用免疫组化法检测所有甲状旁腺组织中TGF-α、EGFR和Ki-67的表达,并分析TGF-α、EGFR表达与SHPT患者临床病理因素的关系。结果:36例SHPT中弥漫性增生17例,结节性增生19例,甲状旁腺的增生类型与患者的年龄、性别、透析时间、术前甲状旁腺激素水平、血钙、血磷、钙磷乘积、血清白蛋白、血红蛋白、尿素氮、肌酐和碱性磷酸酶水平均无明显关系(均P>0.05),TGF-α、EGFR、Ki-67的表达在正常甲状旁腺织、弥漫性增生甲状旁腺织、结节性增生甲状旁腺织中均依次明显升高(均P<0.05)。结论:TGF-α与EGFR在SHPT患者腺体组织中表达增高,且与甲状旁腺细胞的增生方式密切有关。
Objective: To investigate the expression and significance of transforming growth factor-α (TGF-α) and epidermal growth factor receptor (EGFR) in parathyroid gland tissues of patients with secondary hyperparathyroidism (SHPT). Methods: Thirty-six SHPT tissue samples and seven normal parathyroid tissue samples were collected. HE staining showed diffuse hyperplasia and nodular hyperplasia of parathyroid glands. Immunohistochemistry was used to detect the expression of TGF-α, EGFR And Ki-67 expression, and analyze the relationship between TGF-α, EGFR expression and clinicopathological factors in patients with SHPT. Results: Thirty-six cases of diffuse hyperplasia in SHPT, 19 cases of nodular hyperplasia, hyperplasia of parathyroid gland and age, gender, dialysis time, preoperative parathyroid hormone level, serum calcium, phosphorus, calcium P value, serum albumin, hemoglobin, urea nitrogen, creatinine and alkaline phosphatase (P> 0.05). The expression of TGF-α, EGFR and Ki-67 in normal parathyroid tissue, diffuse Hyperplasia of parathyroid tissue, nodular hyperplasia of parathyroid tissue were significantly increased (P <0.05). Conclusion: The expression of TGF-α and EGFR in glandular tissue of SHPT patients is increased, which is closely related to the hyperplasia of parathyroid cells.