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用间接免疫荧光法检测了24例鼻咽癌患者与119例正常人血清中EB病毒4种特异性IgG抗体,结果表明,正常人血清中EB病毒衣壳抗原(WCA)的抗体效价为1:160以下,而鼻咽癌患者血清抗体效价为l:160~1:5120,抗体阳性率均为100%;正常人血清中EB病毒核抗原(EBNA)的抗体效价为1:80以下,而鼻咽患者血清抗体价为1:80~1:2560,阳性率均为100%;正常人血清中EB病毒早期抗原(EA)的抗体效价为l:10,阳性率只有13.3%,而鼻咽癌患者血清抗体效价为l:20~1:1280,阳性率为100%;正常人血清中EB病毒抗原(MA)的抗体效价为1:10~1:40,阳性率为71%,而鼻咽癌患者血清抗体效价为1:10~1:320,阳性率为100%.以上4种抗体中.VCA、EBNA和EA抗体的效价和分布在正常人与鼻咽癌患者之间有明显差异(P<姜勇男,男,31岁,讲师.延吉市局子街21号(133000)0.0l),EA抗体的阳性率也比正常人明显升高(P<0.0l),MA抗体的效价和阳性率与正常人相比无显著差异(P>0.05)。
The indirect immunofluorescence method was used to detect four specific IgG antibodies against Epstein-Barr virus (EBV) in 24 nasopharyngeal carcinoma patients and 119 normal individuals. The results showed that the antibody titer of EB virus capsid antigen (WCA) was 1 in normal human serum. : 160 or less, and serum antibody titer of nasopharyngeal carcinoma patients is 1:160 to 1:5120, the antibody positive rate is 100%; normal human serum EB virus nuclear antigen (EBNA) antibody titer is below 1:80 The serum antibody levels of nasopharyngeal patients ranged from 1:80 to 1:2560 and the positive rate was 100%. The antibody titer of EA virus early antigen (EA) in normal human serum was 1:10, and the positive rate was only 13.3. %, while the serum antibody titer of nasopharyngeal carcinoma patients was 1:20 to 1:1280, the positive rate was 100%; the antibody titer of EB virus antigen (MA) in normal human serum was 1:10 to 1:40, positive The rate was 71%, while the serum antibody titer of nasopharyngeal carcinoma patients was 1:10 to 1:320, and the positive rate was 100%. Above 4 kinds of antibodies. The titers and distributions of VCA, EBNA, and EA antibodies were significantly different between normal and nasopharyngeal cancer patients (P 0.05).