论文部分内容阅读
目的比较不同厂家IFN-γ释放试验诊断试剂盒在临床诊断中的价值,探讨IFN-γ释放试验对临床的指导。方法分别用2个厂家IFN-γ释放试验诊断试剂盒检测临床确诊结核病人,与临床参比试剂盒TSOPT进行平行对比试验。结果与参比产品相比,免疫学方法检测结果与参比试剂没有统计学意义。但对非结核病人,参比试剂阳性预测值较高,临床诊断效果更佳。结论 T-SOPT试验对结核病人诊断结果较准确,可以作为结核病筛查试剂。免疫学法IFN-γ检测试剂盒与T-SOPT有较好的临床相关性,作为筛查试剂,可以满足国内低结核病检出率的现状。
Objective To compare the diagnostic value of IFN-γ release test kit from different manufacturers in clinical diagnosis and to explore the clinical guidance of IFN-γ release test. Methods Two clinically diagnosed tuberculosis patients were tested with two IFN-γ release test diagnostic kits respectively and compared with TSOPT clinical reference kit. Results Compared with the reference product, immunological test results and reference reagents were not statistically significant. But for non-tuberculosis patients, the reference reagent positive predictive value is higher, the clinical diagnosis is better. Conclusion T-SOPT test is more accurate for tuberculosis patients and can be used as TB screening reagent. Immunological IFN-γ detection kit and T-SOPT has a good clinical relevance, as a screening reagent, to meet the status of the detection rate of low-TB in the country.