丝虫是一种以节肢动物为传播媒介的血液和组织内寄生虫,对人类的危害较大。据估计,全世界大约有1.2亿人感染了班氏丝虫、马来丝虫和帝汶丝虫,并有较高的死亡率。目前,有关动物模型研究结果和流行病学数据表明,第三期幼虫(L3)可能是诱导产生保护性免疫反应的主要时期。然而,激发引起保护性免疫反应的抗原尚未鉴定、分离。针对上述情况,本文作者对L3期特异性表达的cDNA进行了分离和鉴定。 Filariasis is an arthropod-based blood and tissue-borne parasite that harms humans. It is estimated that about 120 million people in the world are infected with Bands, Malay and Timothy worms and have high mortality rates. At present, the animal model research results and epidemiological data show that the third larvae (L3) may be the main period of induction of protective immune response. However, the antigen that elicits a protective immune response has not been identified and isolated. In view of the above situation, the author of the L3 specific expression of cDNA was isolated and identified.