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目的:探讨促性腺激素释放激素激动剂(GnRH-a)触发排卵的疗效。方法:对应用氯米芬(CC)、来曲唑(LE)和/或人绝经期促性腺激素(hMG)促排卵治疗的不孕患者,卵泡成熟时给与GnRH-a(A组)或人绒毛膜促性腺激素(hCG)(B组)触发排卵,卵巢过度刺激综合征(OHSS)高危周期则给予GnRH-a,观察比较其临床结局。结果:共分析了81例患者132个促排卵周期,A、B组周期数分别为75和57,组间周期排卵率、多胎率、流产率相似(P>0.05)。周期临床妊娠率、OHSS发生率A组高于B组(P<0.05),无重度OHSS发生。结论:GnRH-a触发排卵临床妊娠率高,可有效预防重度OHSS的发生。
Objective: To investigate the efficacy of gonadotropin-releasing hormone agonist (GnRH-a) triggering ovulation. METHODS: Infertility patients treated with clomiphene citrate (CC), letrozole (LE), and / or human ovulation induction therapy with gonadotropin (hMG), were given GnRH-a (group A) Human chorionic gonadotropin (hCG) (group B) triggers ovulation, while high-risk cycles of ovarian hyperstimulation syndrome (OHSS) give GnRH-a, and its clinical outcome is observed and compared. Results: A total of 132 ovulation cycles were analyzed in 81 patients. The number of cycles in group A and group B was 75 and 57, respectively. The rates of ovulation, multiple births and abortion were similar between the two groups (P> 0.05). The clinical pregnancy rate and the incidence of OHSS in group A were higher than those in group B (P <0.05), and no severe OHSS occurred. Conclusion: GnRH-a triggers ovulation clinical pregnancy rate is high, which can effectively prevent the occurrence of severe OHSS.