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欲作为非胃肠道使用的羧噻吩甲氧青霉素(Temocillin,BRL17421)是一种在其分子结构中的6α位上引入了一个甲氧基的半合成β-内酰胺类抗生素。具体结构为6β(2-羧基-2-噻嗯基-3-乙酰胺基)-6α-甲氧基青霉素酸双钠盐。据已有的报道表明,它对许多革蓝氏阴性菌有抗菌活性,而且对这些菌株产生的β-内酰胺酶具有良好的稳定性。因此作者将羧噻吩甲氧青霉素与其他β-内酰胺类抗生素对新近由临床分离的201株菌进行了体外抗菌活性的比较。作为一起被比较的药物除了氨苄青霉素、羧噻吩青霉素(Ticarcillin)、噻吩甲氧头孢菌素(Cefoxitin)外,
Carnitine (Temocillin, BRL17421), intended for parenteral use, is a semisynthetic beta-lactam antibiotic that incorporates a methoxy group at the 6 alpha position in its molecular structure. The specific structure is 6β (2-carboxy-2-thienyl-3-acetamido) -6α-methoxy penicillin acid disodium salt. It has been reported that it has antibacterial activity against many gram-negative bacteria and that it has good stability to the beta-lactamase produced by these strains. Therefore, the authors compared the antibacterial activity of carbothiophene and other β-lactam antibiotics against newly isolated 201 strains of bacteria in vitro. Drugs to be compared together were, in addition to ampicillin, Ticarcillin, Cefoxitin,