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噻嗪类利尿剂可加重已确诊的糖尿病,但是否能使原来糖耐量良好的患者糖耐量下降,则有争论。作者前瞻性研究了高血压病患者口服噻嗪类利尿剂对糖耐量的影响。 34例高血压病患者,男13例,女21例。开始平均年龄48±10岁。所有患者均连续口服噻嗪类利尿剂14年,其中服苄氟噻(bendrofluazide)6.3mg/d 19例,服双氢克尿噻73mg/d共13例,服环戊甲噻嗪0.5mg/d 2例。在治疗前和治疗后1、6、14年各进行口服糖耐量试验,即早晨空腹饮葡萄糖溶液400ml,测空腹及服糖后30、60、120、150分钟的血糖值。
Thiazide diuretics may aggravate the diagnosis of diabetes, but whether to make the original glucose tolerance in patients with impaired glucose tolerance, it is controversial. The prospective study of hypertensive patients with oral thiazide diuretics on impaired glucose tolerance. 34 cases of hypertensive patients, 13 males and 21 females. The average age at onset 48 ± 10 years old. All patients were consecutive oral thiazide diuretic for 14 years, of which 19 cases were treated with bendrofluazide 6.3 mg / d, 13 cases received hydrochlorothiazide 73 mg / d, 0.5 mg / d 2 cases. Oral glucose tolerance test was carried out before treatment and at 1, 6 and 14 years after treatment, namely morning fasting drink 400ml of glucose solution, fasting blood glucose and 30,60,120,150 minutes after taking blood sugar values.