论文部分内容阅读
目的:建立测定复方氯唑沙宗片中氯唑沙宗血药浓度的方法,并进行其在健康人体药物动力学研究。方法:18名男性健康志愿者单剂量口服复方氯唑沙宗片,高效液相色谱法测定复方氯唑沙宗中氯唑沙宗的血药浓度。结果和结论:此法操作简便、结果可靠。复方氯唑沙宗片中的氯唑沙宗主要药物动力学参数分别为T_(1/2)(0.927±0.3747)h,Tmax(1.403±0.681)h,Cmax(21.063±5.748)mg/L,AUC_(0～6)(51.624±15.202)mg/(L·h),AUC_(0～(?))(53.201±15.142)mg/(L·h)。
OBJECTIVE: To establish a method for the determination of clozapine in compound chlorzoxazone tablets and to study its pharmacokinetics in healthy volunteers. Methods: Eighteen male healthy volunteers were given single dose oral chlorzoxazone tablets, and the content of chlorzoxazone in compound chlorzoxazone was determined by high performance liquid chromatography. Results and Conclusion: This method is simple and reliable. The main pharmacokinetic parameters of chlorzoxazone in the compound chlorzoxazone tablets were T 1/2 (0.927 ± 0.3747) h, Tmax (1.403 ± 0.681) h, Cmax (21.063 ± 5.748) mg / L, AUC_ (0 ~ 6) (51.624 ± 15.202) mg / (L · h), AUC_ (0 ~ (?)) (53.201 ± 15.142) mg / (L · h).