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目的 :探索降低反流胆汁中胆酸浓度的有效国产药物。方法 :以凹凸棒石粉或双八面体蒙脱石 (思密达 )吸附胆汁反流症患者胃液 ,检测并比较吸附前后胃液总胆酸和三羟胆酸含量 ,同时比较凹凸棒石粉剂和双八面体蒙脱石对胆酸的吸附能力。结果 :吸附前三羟胆酸和总胆酸含量分别为 (10 5 .71± 43.35 )μg/ ml和 (2 71.5 0± 77.5 0 )μmol/ L ,经凹凸棒石粉或双八面体蒙脱石吸附后三羟胆酸含量分别为 (32 .32± 18.36 )μg/ m l和 (2 9.13± 17.0 2 )μg/ ml,总胆酸含量分别为 (130 .0 1± 30 .94)μm ol / L与 (76 .90± 41.80 )μm ol/ L ,吸附前后三羟胆酸和总胆酸含量有显著差异 (P<0 .0 1) ,而经凹凸棒石粉或双八面体蒙脱石吸附后三羟胆酸和总胆酸含量无显著差异 (P>0 .0 5 )。 结论 :凹凸棒石粉对胆酸有较强的吸附作用 ,与双八面体蒙脱石无显著差异 ,有良好的临床应用前景。
Objective: To explore effective antihypertensive drugs to reduce cholic acid concentration in reflux bile. Methods: The gastric juice of patients with bile reflux disease was adsorbed by attapulgite powder or dioctahedral smectite (Smectite), the contents of total bile acids and trihydroxycholic acid in gastric juice before and after adsorption were measured and compared. Meanwhile, the effects of attapulgite powder and bis Octahedral montmorillonite adsorption of cholic acid. Results: The contents of pre-adsorbed trihydroxycholic acid and total cholic acid were (105.71 ± 43.35) μg / ml and (2 71.5 ± 77.5 0) μmol / L, respectively. The attapulgite powder or dioctahedral smectite The concentrations of triacylglycine after adsorption were (32.32 ± 18.36) μg / ml and (2 9.13 ± 17.0 2) μg / ml respectively, and the contents of total cholic acid were (130.0 ± 30.94) μmol / L and (76.90 ± 41.80) μmol / L, respectively. There were significant differences in the content of trihydroxycholic acid and total cholic acid before and after adsorption (P <0.01), while the adsorption of attapulgite powder or dioctahedral montmorillonite There was no significant difference in the content of posterior trihydroxycholic acid and total cholic acid (P> 0.05). CONCLUSION: Attapulgite powder has a strong adsorption effect on bile acid, which has no significant difference with double octahedral smectite, and has good clinical application prospect.