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本文对７４例ＳＬＥ患者ＩｇＧ－ＡＣＬ纵行观察四年，就其变化和临床相关性进行分析。３９例ＡＣＬ阳性组中３４例（８７％）的中等至严重活动性ＳＬＥ，而ＡＣＬ阴性组仅１３／３５（３７％）。ＡＣＬ阳性与ＳＬＥ疾病的活动性密切相关。ＡＣＬ阳性组在血栓形成、自发性流产、中枢神经系统损害、血小板下降方面均较ＡＣＬ阴性组有显著的差别。阳性ＡＣＬ组又可分为：持续ＡＣＬ阳性的Ａ组和ＡＣＬ有波动的Ｂ组。Ａ组患者较Ｂ组更容易发生血栓、抗磷脂抗体综合征，特别是脑血栓等中枢神经系统病变，这是ＡＣＬ持续阳性ＬＬＥ患者的临床特征之一。
This article 74 cases of SLE patients IgG-ACL longitudinal observation of four years, its changes and clinical correlation analysis. Thirty-four (87%) of the 39 patients with ACL-positive had moderate to severe active SLE compared to 13/35 (37%) in the ACL-negative group. ACL-positive and SLE disease activity is closely related. ACL-positive group in the thrombosis, spontaneous abortion, central nervous system damage, thrombocytopenia compared with ACL-negative group were significantly different. Positive ACL group can be divided into: persistent ACL-positive A group and ACL fluctuating B group. Patients in group A were more likely to develop thrombosis, antiphospholipid antibody syndromes, and CNS lesions, especially cerebral thrombosis, than those in group B. This is one of the clinical features of patients with persistent LLE with ACL.