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目的探讨阿奇霉素药物不良反应相关因素。方法对31例患者性别、年龄、不良反应累及部位、给药途径及发生时间等临床资料进行回顾性分析。结果 31例阿奇霉素所致不良反应患者临床资料分析可知,年龄<12岁、>60岁患者所占比例较高(38.71%、45.16%)(P<0.05);男性患者所占比例(61.29%)显著高于女性(38.71%)(P<0.05);以皮肤及其附件损害发生率最高(48.39%)(P<0.05);静脉滴注给药后发生不良反应者高达90.32%(P<0.05);80.65%患者给药后30 min内即出现药物不良反应(P<0.05)。结论临床医生应准确掌握阿奇霉素所致不良反应特点及相关因素,给药时应综合患者实际情况从而确定合适的用法用量,有利于提高阿奇霉素使用有效性及安全性。
Objective To investigate the related factors of azithromycin drug adverse reactions. Methods The clinical data of 31 patients with gender, age, affected area, route of administration and time of onset were retrospectively analyzed. Results The clinical data of 31 patients with adverse reactions caused by azithromycin showed that the percentage of male patients (61.29%) was higher than that of patients aged> 12 years and> 60 years (38.71% and 45.16%, P <0.05) (P <0.05). The incidence of skin and its accessory damage was the highest (48.39%) (P <0.05). The rate of adverse reactions after intravenous drip administration was as high as 90.32% (P <0.05) ). Adverse reactions occurred in 80.65% patients within 30 minutes after administration (P <0.05). Conclusion Clinicians should accurately grasp the characteristics of azithromycin-induced adverse reactions and related factors, the drug should be integrated with the actual situation of patients to determine the appropriate dosage, help to improve the effectiveness and safety of azithromycin use.