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目的:探讨氢吗啡酮术后镇痛对直肠癌患者Dixon术后肠功能恢复的影响。方法:选择直肠癌行Dixon术的患者36例,随机分为氢吗啡酮组(H组)和吗啡组(M组),每组18人。两组患者均行静脉自控术后镇痛,其中H组镇痛药物采用氢吗啡酮+昂丹司琼,而MS组则采用吗啡+昂丹司琼。术后常规医疗处理。结果:两组患者在年龄、性别、文化程度无统计学差异(P>0.05)。两组患者术后VAS评分及HR、MAP变化均没有统计学差异(P>0.05)。与M组相比,H组患者术后不良反应的发生率明显降低(P<0.05),肠鸣音恢复时间、术后第一次排气时间和第一次排便时间均明显缩短(P<0.05)。结论:相对于吗啡,氢吗啡酮用于术后镇痛更有利于直肠癌患者术后肠功能的恢复,并减少术后不良反应的发生率。
Objective: To investigate the effect of postoperative hydromorphone postoperative analgesia on the recovery of intestinal function in patients with rectal cancer after Dixon operation. Methods: Thirty-six patients undergoing Dixon surgery for rectal cancer were randomly divided into hydromorphone group (H group) and morphine group (M group), with 18 patients in each group. Patients in both groups underwent intravenous postoperative analgesia. Hydromorphone + ondansetron was used for analgesia in group H, and morphine + ondansetron was used in MS. Postoperative routine medical treatment. Results: There was no significant difference in age, sex and education between the two groups (P> 0.05). There was no significant difference in postoperative VAS score, HR and MAP between the two groups (P> 0.05). The incidence of postoperative adverse reactions was significantly lower in group H than in group M (P <0.05). The recovery time of bowel sounds, the first time of deflation and the time of first defecation were significantly shorter in group H (P < 0.05). Conclusion: Compared with morphine, hydromorphone for postoperative analgesia is more conducive to the recovery of intestinal function in patients with rectal cancer and reduce the incidence of postoperative adverse reactions.