论文部分内容阅读
N-三甲基甲硅烷基咪唑 ( 1 )作为羟基保护剂 [1 ]用于克拉霉素的生产 [2 ]。文献 [3]用三甲基氯甲硅烷和咪唑反应 ,以乙二胺为去酸剂 ,反应时间为 2 d。本文用六甲基二硅氮烷和咪唑反应 ,以硫酸为催化剂制得 1 ,反应时间仅 4 h,收率为 79.4 %实验部分依次加入六甲基二硅氮烷 (
N-trimethylsilyl imidazole (1) as a hydroxyl protective agent [1] for the production of clarithromycin [2]. Reference [3] with trimethylchlorosilane and imidazole reaction to ethylenediamine as acid scavenger, the reaction time was 2 d. In this paper, hexamethyldisilazane and imidazole reaction, sulfuric acid as catalyst 1, the reaction time is only 4 h, the yield was 79.4% Experimental part followed by hexamethyldisilazane (