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目的探讨上皮样血管肉瘤(EAS)的临床病理特点、诊断和鉴别诊断。方法对2例上皮样血管肉瘤的组织病理学、免疫组化结果进行分析,结合文献进行讨论。结果镜下肿瘤由细胞体积大、胞质丰富、具有上皮样特征的瘤细胞构成。瘤细胞呈弥漫片状、腺管状、单排条索状排列。免疫组化:肿瘤细胞CD34和FⅧAg(+),AE1/AE3和EMA部分(+)。结论上皮样血管肉瘤是一种罕见的高度恶性肿瘤,诊断和鉴别诊断主要依赖其病理形态学特点结合免疫表型。
Objective To investigate the clinicopathological characteristics, diagnosis and differential diagnosis of epithelioid angiosarcoma (EAS). Methods Two cases of epithelioid angiosarcoma histopathology, immunohistochemistry results were analyzed, combined with the literature to be discussed. Results Microscopic tumor was composed of tumor cells with large cell volume, abundant cytoplasm and epithelial-like features. Tumor cells were diffuse lamellar, glandular tubular, single-row cord-like arrangement. Immunohistochemistry: Tumor cells CD34 and FⅧAg (+), AE1 / AE3 and EMA fractions (+). Conclusions Epithelioid angiosarcoma is a rare and highly malignant tumor. The diagnosis and differential diagnosis mainly depend on its pathomorphological features and immunophenotype.