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目的研究急性胰腺炎(acute pancreatitis,AP)的灌注参数与临床严重程度的相关性,均行CT增强扫描。方法前瞻性纳入经临床明确诊断的急性胰腺炎患者95例,因其它原因行CT检查且胰腺正常者71例作为对照组。采用PHILIPS公司提供的灌注软件计算胰腺灌注数据(BF,BV,MTT)并进行统计学处理。结果(1)对照组,胰腺头部的灌注量(BF):(63.7±22.1)ml.100 g-1.min-1;体部(72.6±23.3)ml.100 g-1.min-1;尾部(72.0±20.1)ml.100 g-1.min-1。(2)急性胰腺炎组,95例患者中有50例临床资料符合Ranson分级要求,其中19例轻症,23例中症,8例重症。轻症胰腺体部的BF为(53.2±14.9)ml.100 g-1.min-1;中症胰腺体部的BF为(48.8±21.4)ml.100 g-1.min-1;重症胰腺体部的BF为(30.4±17.2)ml.100 g-1.min-1。结论CT灌注参数可以作为判断急性胰腺炎严重程度的量化指标。
Objective To study the relationship between perfusion parameters and clinical severity in patients with acute pancreatitis (AP). All patients underwent enhanced CT scan. Methods A total of 95 patients with acute pancreatitis diagnosed clinically were enrolled prospectively. Totally 71 patients with normal pancreatic function underwent CT examination for other reasons. Pancreatic perfusion data (BF, BV, MTT) were calculated and statistically analyzed using perfusion software provided by PHILIPS. Results: (1) In the control group, the amount of perfusion (BF) in the head of the pancreas was (63.7 ± 22.1) ml.100 g-1.min-1 and that in the body was (72.6 ± 23.3) ml.100 g-1.min- ; Tail (72.0 ± 20.1) ml.100 g-1 min-1. (2) In the group of acute pancreatitis, clinical data of 50 out of 95 patients met the Ranson classification requirements. Among them, 19 were mild, 23 were moderate, and 8 were severe. BF of mild pancreatic body was (53.2 ± 14.9) ml.100 g-1.min-1; BF of moderate pancreatic body was (48.8 ± 21.4) ml.100 g-1.min-1; Body BF was (30.4 ± 17.2) ml.100 g-1.min-1. Conclusion CT perfusion parameters can be used as quantitative indicators to determine the severity of acute pancreatitis.