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目的 探讨Tourette综合征 (TS)患儿血兴奋性氨基酸 (excitatoryaminoacid ,EAAs)及性激素水平变化与TS的关系。方法 东南大学附属中大医院分别应用高效液相色谱法 (HPIC)和放射免疫分析法 (RIA)检测了 1999～ 2 0 0 2年收治的 15例TS患儿血浆谷氨酸 (GLU)、天冬氨酸 (ASP)水平及血清睾酮 (T)、雌二醇 (E2 )和孕酮 (P)质量浓度。同时与 2 0例对照组儿童进行比较。结果 (1) 15例TS患儿血浆GLU水平明显高于对照组 (P <0 0 1) ,两组血浆ASP比较差异无显著性 (P >0 0 5 )。 (2 )TS患儿血清T质量浓度较对照组显著升高 (P <0 0 1) ,血清E2质量浓度在TS组略有降低 ,但与对照组比较差异无显著性 (P>0 0 5 )。 (3)TS患儿血清P较对照组显著降低 (P<0 0 1)。血清T/E2 比值和T/P比值均较对照组显著升高 (P <0 0 1)。 (4 )TS组血浆EAAs与血清T呈正相关(r =0 897,P <0 0 1)。结论 (1)TS患儿存在EAAs质量浓度变化 ,GLU可能参与TS的病理生理过程。 (2 )性激素比例失衡可能与TS发病有密切关系。 (3)EAAs和性激素与TS发病存在相关性。
Objective To investigate the relationship between TSA and serum levels of excitatory amino acids (EAAs) and sex hormones in children with Tourette’s syndrome (TS). Methods The rats of TSU affiliated to Southeast University were tested for plasma glutamic acid (GLU) in 15 children with TS from 1999 to 2002 by high performance liquid chromatography (HPLC) and radioimmunoassay (RIA) Aspartate (ASP) levels and serum testosterone (T), estradiol (E2) and progesterone (P) mass concentration. At the same time with 20 cases of control group children were compared. Results (1) Plasma GLU levels in 15 children with TS were significantly higher than those in the control group (P <0.01). There was no significant difference in plasma ASP between the two groups (P> 0.05). (2) Serum T concentration in children with TS was significantly higher than that in control group (P <0.01), and the serum E2 level was slightly lower in TS group, but there was no significant difference between the two groups (P> 0.05) ). (3) Serum P in children with TS was significantly lower than that in control group (P <0.01). Serum T / E2 ratio and T / P ratio were significantly higher than the control group (P <0.01). (4) There was a positive correlation between plasma EAAs and serum T in TS group (r = 0 897, P <0.01). Conclusion (1) TS children with changes in the concentration of EAAs, GLU may be involved in the pathophysiology of TS. (2) imbalance of sex hormones may be closely related to the pathogenesis of TS. (3) there is a correlation between EAAs and sex hormones and the pathogenesis of TS.