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绵毛黄芪总甙(As)是新疆塔城地区绵毛黄芪(Astragalus sieversianus Pall)提取物,由中国科学院新疆分院化学所植化室提供。本文探讨了As对CR小鼠的免疫功能的影响。1 对小鼠碳粒廓清作用的影响ICR小鼠随机分5组:溶剂对照组,ig As 50mg/kg、75mg/kg给药组,As75mg/kg加环磷酰胺(Cy)110mg/kg组及scCy组(10mg/kg),给药7d。按常规方法测定并计算廓清指数(K)值。结果给药组分别为26.45+9.46及21.66±8.73,与对照组10.01±3.08比较P<0.01;Cy组为5.01±2.87,与As+Cy组11.89+4.82比较P<0.05。表明As能提高小鼠吞噬能力。2 对小鼠血清溶血素生成的影响ICR小鼠分组及给药方法同上。于给药第3d ip37.5％,SRBC 0.2ml致敏,致敏1h后,小鼠取血测定其半数溶血值(HC_(56)~-).结果As组分别为140.17±44.23及178.18±25.10,与对照组73.34±42.14比较P<0.01)。Cy组30.66±12.63与As+Cy组71.53±29.41比较P<0.01。表明As能促进小鼠抗体生成.
Astragalus sieversianus Pall is an extract from Astragalus sieversianus Pall in the Tacheng area of Xinjiang, China. It is provided by the Department of Chemistry, Institute of Chemistry, Xinjiang Branch of the Chinese Academy of Sciences. This article explored the effect of As on immune function in CR mice. 1 Effect on carbon clearance of mice ICR mice were randomly divided into 5 groups: solvent control group, ig As 50 mg/kg, 75 mg/kg administration group, As75 mg/kg plus cyclophosphamide (Cy) 110 mg/kg group and The scCy group (10 mg/kg) was administered for 7 days. The clearance index (K) value was determined and calculated according to conventional methods. The results of the treatment group were 26.45 + 9.46 and 21.66 ± 8.73, compared with the control group 10.01 ± 3.08 P <0.01; Cy group was 5.01 ± 2.87, compared with the As + Cy group 11.89 + 4.82 P <0.05. It was shown that As can increase the phagocytic ability of mice. 2 Effect on mouse serum hemolysin ICR mice were grouped and administered as above. On the 3d ip 37.5%, SRBC 0.2ml sensitized and sensitized for 1h, the mice were taken blood to determine their half hemolytic value (HC_(56)~-). The results of the As group were 140.17±44.23 and 178.18±, respectively. 25.10, P<0.01 compared with control group 73.34±42.14. The Cy group 30.66±12.63 compared with the As+Cy group 71.53±29.41 P<0.01. It shows that As can promote mouse antibody production.