目的研究α受体颉颃剂吲哚拉明的镇痛作用。方法先建立小鼠神经痛模型,再用热板法测定小鼠缩爪反应潜伏期,观察注射吲哚拉明后小鼠痛阈值的变化。然后还观察了腹腔注射冰醋酸引起的内脏痛在注射了吲哚拉明后小鼠扭体次数的不同。结果在热板法和醋酸法分别注射了3mg/kg和3.5mg/kg吲哚拉明后,小鼠的缩爪反应潜伏期明显增加(P<0.01)和扭体次数显著减少(P<0.01)。结论α受体颉颃剂吲哚拉明对外创性神经痛病理模型或正常小鼠具有镇痛作用。 Objective To study the analgesic effect of α-receptor antagonist indolinamine. Methods The model of neuralgia in mice was established. The incubation period of mice retraction reaction was measured by hot plate method. The changes of pain threshold in mice after injection of indolinamine were observed. Then it was observed that intra-abdominal injection of acetic acid-induced visceral pain in mice injected with indolinamine different number of writhing. Results After incubation with 3 mg / kg and 3.5 mg / kg indolamine respectively, the incubation period of clawed mice increased significantly (P <0.01) and the number of writhing decreased significantly (P <0.01) . Conclusions Indoleamine, an antagonist of α receptor, has an analgesic effect on the pathological model of traumatic neuralgia or in normal mice.