低钠血症是充血性心力衰竭的严重表现,通过限制水摄入,补充钠盐和利尿等常规治疗效果不理想。精氨酸血管加压素受体拮抗剂,是一种排水利尿剂,能促进肾集合管自由水的排泄,同时能维持血循环中钠和其它电解质浓度,对充血性心力衰竭的治疗有效。精氨酸血管加压素受体拮抗剂与血管紧张素转换酶抑制剂联合应用,能进一步使血管扩张,减少容量超负荷和纠正低钠血症,改善心功能。 Hyponatremia is a serious manifestation of congestive heart failure, by limiting water intake, sodium supplementation and diuretics and other conventional treatment results are not satisfactory. Arginine vasopressin receptor antagonist is a drainage diuretic that promotes the excretion of free water in the renal collecting tube while maintaining the sodium and other electrolyte concentrations in the blood circulation and is effective in the treatment of congestive heart failure. Arginine vasopressin receptor antagonist in combination with angiotensin-converting enzyme inhibitors, can further vasodilatation, reduce capacity overload and correct hyponatremia, improve cardiac function.