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目的评价难治性非霍奇金淋巴瘤(NHL)治疗方法。方法以EP+COP方案治疗36例难治性非霍奇金淋巴瘤,其中20例CHOP方案治疗后达完全缓解后复发,12例多个疗程(COP、CHOP)治疗后未缓解或病情进行性恶化,4例为初治但心电图有T波及ST段改变且病理为高度恶性。结果36例患者治疗后完全缓解率为61.1%(22/36),总有效率为83.3%(30/36)。2、3年生存率为55.6%(20/36)、44.4%(16/36)。主要毒副反应为骨髓抑制和胃肠道反应,外周神经炎。结论EP+COP方案治疗难治性非霍奇金淋巴瘤具有疗效确切,毒副反应小,且价格便宜的优点。
Objective To evaluate the treatment of refractory non-Hodgkin’s lymphoma (NHL). Methods Thirty-six patients with refractory non-Hodgkin’s lymphoma were treated with EP + COP regimen. Twenty patients underwent complete remission after treatment with CHOP regimen. After 12 courses of treatment (COP, CHOP), they were not relieved or progressed Worsening, 4 cases of newly diagnosed but ECG T wave and ST segment changes and the pathology is highly malignant. Results The complete remission rate of 36 patients after treatment was 61.1% (22/36) and the total effective rate was 83.3% (30/36). 2, 3-year survival rate was 55.6% (20/36), 44.4% (16/36). The main side effects of bone marrow suppression and gastrointestinal reactions, peripheral neuritis. Conclusion The EP + COP regimen is effective in treating refractory non-Hodgkin’s lymphoma with less toxic and side effects and lower cost.