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作者采用随机双盲方法评价维生素A治疗严重麻疹的疗效。 189例有并发症(肺炎、腹泻或哮吼)的麻疹患儿,在出疹的5天内,92例随机接受维生素A,总量为40万U(120mg),入院时用半量,余量第2天一次给予,口服或鼻饲,或安慰剂(97例)治疗。结果发现,本组患儿罕见维生素A缺乏的临床表现,但血清视黄醇水平显著降低(0.405±0.021μmol/ml),92%有低视黄醇血症(血清视黄醇水平<0.7μmol/L)。血清视黄醇结合蛋白浓度和白蛋白也降低。与安慰剂相比,接受维生素A治疗的患儿肺炎恢复较快,腹泻时间缩短(p=0.001),哮吼病
The authors used a randomized double-blind method to evaluate the efficacy of vitamin A in the treatment of severe measles. Of the 189 children with measles who had complications (pneumonia, diarrhea, or croak), 92 were randomized to receive either 400 mg U (120 mg) of vitamin A within 5 days of the rash and half, Given once daily, orally or nasally, or placebo (97 cases). The results showed that rare clinical manifestations of vitamin A deficiency in this group of patients, but serum retinol levels were significantly lower (0.405 ± 0.021μmol / ml), 92% of patients with hyponatremia (serum retinol levels <0.7μmol / L). Serum retinol binding protein concentrations and albumin also decreased. Pneumonia recovered faster in children treated with vitamin A compared with placebo, diarrhea was shorter (p = 0.001), croup disease