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曾有报道甲苯咪唑实验治疗鼠类旋毛虫病有效。本文作者曾在旋毛虫的侵入期,即感染的第14至18天,每天经口喂以甲苯咪唑50mg/kg连续给药5天,在感染后45天解剖,肌肉内的幼虫减少率达96%,表明旋毛虫第1期幼虫对该药敏感。本文作者又进行了以下的实验观察:(一)对经口感染200～250条旋毛虫幼虫的小鼠,于感染后14～16天每天喂服甲苯咪唑3.125、6.25或12.5mg/kg2次,连续3天。于感染的63天解剖,检计肌肉中幼虫数,并与对照组比较,以上3个剂量组的幼虫减少率依次为75%、82%与
It has been reported that mebendazole is effective in treating murine trichinosis. The author of this article has been administered orally with mebendazole 50 mg / kg orally daily for 5 days at the invasion phase of Trichinella, ie on the 14th to 18th day of infection and dissected on the 45th day after infection, and the intramuscular larval reduction rate reached 96 %, Indicating that the first phase of Trichinella larvae sensitive to the drug. The authors also conducted the following experimental observations: (a) orally infected with 200 to 250 trichinella larvae mice, 14 to 16 days after infection mebendazole 3.125,6.25 or 12.5mg / kg twice a day, 3 consecutive days. Sixty-three days after infection, the number of larvae in the muscle was determined and compared with the control group. The larval reduction rates of the above three dose groups were 75%, 82% and