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作者报告一例哌替啶过敏并经对哌替啶特异的IgE 抗体证实。病例:女,2(1/2)岁,12kg。因直肠出血拟行乙状结肠镜检。无过敏及哮喘史。一年前因咳嗽曾用含可待因的药物。查体无特殊。静注哌替啶25mg一分钟内面部出现荨麻疹伴咳嗽。给苯海拉明25mg,但又立即发生哮鸣和紫绀。面罩给氧无效。脉搏不清,即行心肺复苏。气管插管并吸出大量泡沫样分泌物。肾上腺素1mg 分次给予。生理盐水500ml 输注至收缩压达90mmHg。发生强直性阵挛,用苯巴比妥、安定。纯氧通气开始时 pH7.25、Pa—CO_250mmHg、PaO_280mmHg。胸片示肺水肿,心电图示窦性心动过速。用8cmH_2O 压力作 PE—
The authors report a case of pethidine allergy and confirmed by pethidine-specific IgE antibodies. Case: Female, 2 (1/2) years old, 12kg. Due to rectal bleeding to be performed sigmoidoscopy. No history of allergies and asthma. A year ago because of cough with codeine drugs. No special examination. Intravenous pethidine 25mg One minute facial urticaria with cough. Diphenhydramine 25mg, but immediately wheezing and cyanosis. Mask oxygen to invalid. Pulse is not clear, that is, cardiopulmonary resuscitation. Endotracheal intubation and suction a lot of foam-like secretions. Adrenaline 1mg graded. 500ml saline infusion systolic pressure up to 90mmHg. Ankylosing clonus, phenobarbital, stability. Pure oxygen ventilation at the beginning of pH7.25, Pa-CO_250mmHg, PaO_280mmHg. Chest radiograph showed pulmonary edema, ECG showed sinus tachycardia. With 8cmH_2O pressure for PE-