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本文对teicoplanin的化学、作用机制、抗菌谱、药代动力学、临床用途、副作用、剂量和用法作了述评。化学 teicoplanin是20世纪70年代中期分离出的一种与万古霉素相似的新糖肽,是Actinoplanes teicomyceticus的发酵产物。它结构复杂,含有由六个脂肪酸相互连接的一个普通的糖苷配基。亲脂性比万古霉素高50～100倍。作用机制 teicoplanin的作用机制与万古霉素相似,通过与肽聚糖分子中D-丙氨酰基-D-丙氨酸末端结合阻止肽聚糖的聚合作用,从而抑制细胞壁的生物合成。抗菌谱体外活性与万古霉素相似,对
This article reviews the chemistry, mechanism of action, antimicrobial spectrum, pharmacokinetics, clinical use, side effects, dosage, and usage of teicoplanin. Chemical teicoplanin is a new glycopeptide similar to vancomycin isolated in the mid-1970s and is a fermentation product of Actinoplanes teicomyceticus. It is complex in structure and contains a common aglycone linked to each other by six fatty acids. Lipophilic than vancomycin 50 to 100 times. Mechanism of Action The mechanism of action of teicoplanin is similar to that of vancomycin, inhibiting the biosynthesis of cell walls by blocking the polymerization of peptidoglycan with the terminal D-alanyl-D-alanine in the peptidoglycan molecule. Antibacterial activity in vitro and vancomycin similar, right