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目的研究长期给予去卵巢大鼠一定剂量人参粉对其血生化及部分脏器相关指标的影响。方法分别以0.5、1、3g/kg·bw-d人参粉掺入基础饲料喂饲大鼠90 d,另设给予基础饲料的假手术组及去卵巢大鼠对照组;试验结束取血测定血清部分生化指标;去取部分脏器测定脏器系数进行病理检查,比较各组差异。结果给予不同剂量人参粉的去卵巢大鼠肾上腺/体重比,子宫/体重比与去卵巢大鼠对照组比较有所增加,体重及血清TP、Alb、TC、TG与去卵巢大鼠对照组比较有所减少,且差异显著(P<0.05)并呈现一定的剂量反应关系。结论一定剂量人参粉长期喂养去卵巢大鼠能够对其血生化指标及脏器相关指标有一定的调节作用,预示了其可能潜在的改善妇女围绝经期症状的作用。
Objective To study the effects of a dose of ginseng powder given to ovariectomized rats on blood biochemistry and related indicators of some organs. Methods Rats were fed with basal diet supplemented with 0.5, 1, 3 g / kg · bw-d ginseng powder for 90 days respectively. Sham operation group and ovariectomized control group were given basal diet. Some biochemical indicators; to take some organs to measure organ coefficient for pathological examination, comparing the differences between groups. Results The adrenal / body weight ratio and the ratio of uterus / body weight of ovariectomized rats with different dosages of ginseng powder increased compared with that of the ovariectomized rats. The body weight, serum TP, Alb, TC, TG and ovariectomized rats Decreased significantly (P <0.05), and showed a dose-response relationship. Conclusion Long-term feeding of a dose of ginseng powder to ovariectomized rats can regulate its blood biochemical parameters and organ-related indexes, indicating that it may potentially improve the perimenopausal symptoms in women.