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目的 评价国产辛伐他汀调节血脂的疗效及安全性。方法 12 2例原发性高脂血症病人随机分入国产辛伐他汀 (6 1例 )组和进口辛伐他汀 (舒降之 ,6 1例 )组。剂量 10mg ,每日 1次 ,疗程 12周。结果 辛伐他汀组降低胆固醇、甘油三酯和动脉粥样硬化指数的有效率分别为 86 .9%、6 5 .6 %和 73.8% ,与进口辛伐他汀组无显著差异。两组不良反应发生率分别为13 1%和 16 4% ,无显著差异。结论 国产辛伐他汀治疗高脂血症与进口辛伐他汀一样有效、安全。
Objective To evaluate the efficacy and safety of domestic simvastatin in the regulation of blood lipids. Methods Twelve patients with primary hyperlipidemia were randomly divided into the group of domestic simvastatin (6 1) and the group of imported simvastatin (SHR, 61). Dose 10mg, 1 day, treatment for 12 weeks. Results The effective rates of reducing cholesterol, triglyceride and atherosclerosis index in simvastatin group were 86.9%, 65.6% and 73.8%, respectively, which were not significantly different from those in simvastatin group. The incidence of adverse reactions in both groups was 13 1% and 16 4%, respectively, with no significant difference. Conclusion Domestic simvastatin treatment of hyperlipidemia and imported simvastatin as effective and safe.