目的:综述铜绿假单胞菌群体感应系统研究进展,从而寻找铜绿假单胞菌治疗的新方向。方法:查阅近年来国内外相关文献并对其进行总结。结果:群体感应系统是细菌依赖细胞密度,通过自诱导分子进行细胞间交流的信号传递系统。当自诱导分子达到阈值时启动群体感应系统从而调节基因表达。结论:群体感应系统参与细菌毒素的释放和生物膜的形成,因此通过抑制群体感应系统降低铜绿假单胞菌的致病性和耐药性成为抗感染治疗药物新靶点。 OBJECTIVE: To summarize the research progress of Pseudomonas aeruginosa population sensing system in order to find a new direction for the treatment of Pseudomonas aeruginosa. Methods: To review the relevant literature at home and abroad in recent years and summarize it. Results: The population-sensing system is a signal-dependent system of bacteria dependent on cell density and cell-to-cell communication through self-induced molecules. When a self-induced molecule reaches a threshold, a population sensing system is activated to regulate gene expression. Conclusion: The population-sensing system is involved in the release of bacterial toxins and the formation of biofilms. Therefore, it is a new target for anti-infectives to reduce the pathogenicity and drug resistance of Pseudomonas aeruginosa by inhibiting the population-sensing system.