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探讨了炎性细胞因子白细胞介素１（ＩＬ－１）和肿瘤坏死因子（ＴＮＦ）在大鼠Ｃ－ＢＳＡ肾炎中的变化及加用外源性前列腺素Ｅ＿１（ＰＧＥ＿１）对这些因子的调节作用。结果表明：Ｃ－ＢＳＡ肾炎模型血清ＩＬ－１和ＴＮＦ均较对照明显升高。加用ＰＧＥ＿１则明显抑制ＩＬ－１和ＴＮＦ活性水平并改善血栓素一前列环素平衡，同时２４小时尿蛋白定量显著下降，肾脏病理变化减轻。结果提示：ＩＬ－１、ＴＮＦ在肾炎发病机理中可能起了重要作用，外源性ＰＧＥ＿１可以抑制其产生和释放并缓解病情发展。
To investigate the changes of inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor (TNF) in rat C-BSA nephritis and the effects of exogenous prostaglandin E_1 (PGE_1) on these factors . The results showed that serum IL-1 and TNF in C-BSA nephritis model were significantly higher than those in control. The addition of PGE 1 significantly inhibited the activity of IL-1 and TNF and improved the balance of thromboxane and prostacyclin, meanwhile, the proteinuria of 24-hour urine protein decreased significantly, and the pathological changes of kidney were alleviated. The results suggest that IL-1 and TNF may play an important role in the pathogenesis of nephritis. Exogenous PGE 1 can inhibit its production and release and alleviate the progression of the disease.