The traditional view of the regulation of eicosanoid formation holds that agonists have to activate receptor-coupled phospholipases before eicosanoid syntheiss can be initiated. Action of phospholipases results in an increase in the intracellular concentration of unesterified arachidonic acid (AA). Once unesterified AA is present in sufficient amounts it can be metabolized by a variety of enzymes that catalyze The traditional view of the regulation of eicosanoid formation holds that agonists have to activate receptor-coupled phospholipases before eicosanoid syntheiss can initiated. Action of phospholipases results in an increase in the intracellular concentration of unesterified arachidonic acid (AA). Once unesterified AA is present in sufficient amounts it can be metabolized by a variety of enzymes that catalyze