论文部分内容阅读
人类基因组中一半的基因可以在中枢神经系统中表达,其中约20%的基因仅在中枢神经系统中表达,许多神经系统疾患不仅有特异基因产物的表达异常,更表现为蛋白质之间的相互作用。大部分中枢神经系统疾病为多因素共同作用,通过比较正常人与患者、不同疾病的患者、及同一疾病不同严重程度的患者,甚至同一患者不同时期及治疗前后蛋白质表达,可以找到与疾病密切相关的疾病特异性蛋白(disease-specific proteins,DSPs),对其进行发病机制研究。在神经系统脱髓鞘疾病标志物研究中,通常采用差异蛋白质组学方法研究体液、脑组织的差异性蛋白,以寻找可能与疾病相关的候选标志物。
Half of the human genome can be expressed in the central nervous system, of which about 20% of genes are expressed only in the central nervous system. Many diseases of the nervous system include not only abnormal expression of specific gene products but also protein-protein interactions . Most central nervous system diseases are multifactorial and can be closely related to the disease by comparing normal and patient, patients with different diseases, patients with different severity of the same disease, and even protein expression at different times and before and after treatment in the same patient Of disease-specific proteins (DSPs), the study of its pathogenesis. In the study of neurodegenerative demyelinating disease markers, differential proteomics is often used to study differential proteins in body fluids and brain tissues in search of candidate markers that may be associated with the disease.