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本实验利用紫外分光光度法,以双黄连栓中的主要有效成分黄芩甙、绿原酸为控制指标,测定四种不同工艺和基质的双黄连栓剂的体外释放浓度和人体血清浓度,并用电子计算机求出四种栓剂的AUC、C_(mix)、T_p及成组t检验和生物利用度。实验结果,4号栓无论是在体外释放度,还是在人体生物利用度方面,均优于其它三种栓剂,可在一定条件下取代静脉注射剂用于重症者的治疗;3号拴剂可作为重症者静注后维持血药浓度的有效制剂或应用于较轻患者。
In this experiment, ultraviolet spectrophotometry was used to determine the in vitro release concentration and human serum concentration of Shuanghuanglian suppository with four different technologies and substrates using the main effective components of Shuanghuanglian suppository, astragalus and chlorogenic acid, as control indicators. The AUC, C_(mix), T_p and group t test and bioavailability of four suppositories were determined. As a result of the experiment, No. 4 suppositories were superior to the other three suppositories both in terms of in vitro release and in terms of human bioavailability. Instead of intravenous injections, they can be used for the treatment of severe cases under certain conditions; No. 3 tanning agent can be used as The severe drug maintains the blood drug concentration after intravenous injection or is applied to lighter patients.