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新近,对突然停用抗高血压药物的后果引起了注意,但估价这一现象的研究不多。目前的资料显示,在各种不同程度的高血压患者中突然停用药物所致的停药后综合征发生率是很低的,其与用药剂量有关,在联合应用某些抗高血压药物(中枢作用抗肾上腺素能和β-阻滞剂)时较为多见。本文对有关停药后综合征的文献进行评价,以提供更为准确的定义,以期对其临床表现、机制、预防和处理有更多的了解。
Recently, attention has been drawn to the consequences of the sudden discontinuation of antihypertensive drugs, but few studies have evaluated this phenomenon. The current data show that in a variety of patients with varying degrees of sudden withdrawal of drug-induced withdrawal syndrome rate is very low, and dose-related, combined use of certain antihypertensive drugs ( Central role of anti-adrenergic and β-blockers) is more common. This article reviews the literature on post-discontinuation syndrome to provide a more accurate definition with a view to gaining a better understanding of its clinical manifestations, mechanisms, prevention and management.