一、临床资料患者,63岁,男性,于2011年8月初体检时发现肝脏肿物,查相关抗原示CEA增高,后行PET/CT检查示乙状结肠不规则结节状高代谢病灶,考虑乙状结肠癌可能,病灶周围多发淋巴结转移,肝脏多发转移。肠镜检查示乙状结肠距肛门26~29cm见一大小约3×4cm菜花样肿物,病理活检示结肠低分化腺癌,KRAS基因检测野生型。后入组临床研究,行FOLFOX4方案化疗,用药方案:奥沙利铂85mg/m2,静脉滴 First, the clinical data Patients, 63 years old, male, liver tumor was found at the beginning of August 2011 physical examination, check the relevant antigen showed increased CEA, PET / CT examination showed irregular sigmoid colon nodular high metabolic lesions, consider sigmoid colon cancer May, multiple lesions around the lymph node metastasis, multiple liver metastases. Colonoscopy shows the sigmoid colon from the anus 26 ~ 29cm see a size of about 3 × 4cm cauliflower tumor, pathological biopsy showed poorly differentiated colon adenocarcinoma, KRAS gene detection wild type. After entering the group clinical study, FOLFOX4 regimen chemotherapy, drug regimens: oxaliplatin 85mg / m2, intravenous drip