The continuous dehydration of D-glucose into 5-hydroxymethylfurfural(HMF) was carried out under mild conditions,using SO3H-functionalized acidic ionic liquids as catalysts and H2O-4-methyl-2-pentanone(MIBK) biphasic system as solvent.High glucose conversion of 97.4% with HMF yield of 75.1%was obtained at 120 8C for 360 min,also,small amounts of levulinic acid(LA) and formic acid were generated.Generally,the dosage of catalyst and the initial content of glucose influenced the reaction significantly; the HMF selectivity decreased with the excessive elevation of temperature and prolonging of time; and water content in the system had a negative effect on the reaction.The ionic liquid catalyst could be recycled and exhibited constant activity for five successful runs.This paper provided a new strategy for HMF production from glucose. The continuous dehydration of D-glucose into 5-hydroxymethylfurfural (HMF) was carried out under mild conditions, using SO3H-functionalized acidic liquids as catalysts and H2O-4-methyl-2-pentanone (MIBK) biphasic system as solvent. conversion of 97.4% with HMF yield of 75.1% was obtained at 120 8C for 360 min, also, small amounts of levulinic acid (LA) and formic acid were generated. Generalized, the dosage of catalyst and the initial content of glucose influenced the reaction the HMF selectivity decreased with the excessive elevation of temperature and prolonging of time; and water content in the system had a negative effect on the reaction. ionic liquid catalyst could be recycled and exhibited constant activity for five successful runs.This paper provided a new strategy for HMF production from glucose.