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目的 探讨非小细胞肺癌 (NSCLC)血管内皮生长因子 (VEGF)的表达水平与CT增强程度的关系 ,从影像学角度评价肿瘤血管生成在肺癌诊断、治疗及淋巴结转移中的临床价值。方法 对 30例NSCLC病人进行动态螺旋CT扫描 (SCT) ,测量病灶增强幅度 ,并利用免疫组化技术检测VEGF。对病灶增强值、VEGF阳性表达及淋巴结转移情况进行统计学分析。结果 30例肺癌病人CT增强值均数为 (36 .2 8± 6 .41 )HU ,VEGF阳性表达 2 1例 ,阴性表达 9例。VEGF在中晚期的阳性表达高于早期病人 (Ρ<0 .0 5) ,淋巴结转移组高于非淋巴结转移组 (Ρ <0 .0 5) ;癌灶增强值与VEGF阳性表达、肿瘤分期及淋巴结转移亦呈正相关。结论 NSCLC的CT增强程度能够反映肿瘤的血管生成 ,并与淋巴结转移密切相关 ,有助于肺癌的诊断、TNM分期 ,而且可以从肿瘤分子生物学行为方面补充目前肺癌分期方法的不足
Objective To investigate the relationship between the expression of vascular endothelial growth factor (VEGF) and the degree of CT enhancement in non-small cell lung cancer (NSCLC) and to evaluate the clinical value of tumor angiogenesis in the diagnosis, treatment and lymph node metastasis of lung cancer. Methods Thirty patients with non-small cell lung cancer (NSCLC) underwent dynamic spiral CT scan (SCT). The extent of lesion enhancement was measured. VEGF was detected by immunohistochemistry. The enhancement value of tumor, VEGF positive expression and lymph node metastasis were statistically analyzed. Results The mean value of CT enhancement in 30 patients with lung cancer was (36.28 ± 6 .41) HU, the positive expression of VEGF was 21 and the negative expression was 9. The positive expression of VEGF in the advanced stage was higher than that in the early stage (P <0.05), the lymph node metastasis was higher than the non-lymph node metastasis (P <0.05) Lymph node metastasis also showed a positive correlation. Conclusion CT enhancement of NSCLC can reflect tumor angiogenesis and is closely related to lymph node metastasis, which is helpful for the diagnosis of lung cancer and TNM staging. It can also supplement the current lung cancer staging method from the aspects of tumor molecular biology