论文部分内容阅读
由于塑料工业日益发展,塑料制品的使用越来越广。医院自配制剂亦改用聚乙烯塑料瓶来分装。在分装含碘制剂后,发现药物的外观颜色变化较大。为了确保药品质量,我们对常用的几种含碘制剂的质量变化做了实验研究。一、材料和方法: 1.材料:(1)复方碘滴鼻液 (2)复方碘溶液 (3)5％碘酊 (4)碘甘油 2.方法: (1)取一定量的上述制剂,分别以Na_2S_2O_3标准液滴定至无色即为终点,计算其碘的百分含量。 (2)上述制剂分别以塑料容器分装,每瓶10ml,塑料瓶瓶口熔封,玻璃瓶密塞。室温放置,每15天测定含量一次,观察药液的外观变化并记录。二、实验结果: 经过三个月的观察,碘含量及外观变化情况见表。三、结果分析: 实验所见,4种含碘制剂存放在塑料瓶或玻璃瓶中,碘含量都有不同程度的下降,又以
Due to the growing plastic industry, the use of plastic products is more and more widely used. Hospital self-formulated with polyethylene plastic bottles to change packaging. In the dispensing of iodine-containing preparations, found that the appearance of the drug color changes. In order to ensure the quality of medicines, we made some experimental studies on the quality changes of several commonly used iodine-containing preparations. Materials and methods: 1. Materials: (1) compound iodine nasal solution (2) compound iodine solution (3) 5% iodine tincture (4) iodine glycerin 2. Method: (1) take a certain amount of the above preparation, Na_2S_2O_3 standard solution titration to colorless is the end point, calculate the percentage of iodine. (2) The above preparations were separately dispensed in plastic containers, each bottle 10ml, plastic bottle bottle mouth seal, glass bottle sealed. Place at room temperature, once every 15 days determination of content, observe the appearance of liquid changes and record. Second, the experimental results: After three months of observation, iodine content and appearance of the changes in the table. Third, the results of the analysis: The experiment shows that four kinds of iodine-containing preparations stored in plastic bottles or glass bottles, iodine content has varying degrees of decline, again