RNA干扰(RNAi)是一种在动植物中广泛存在的通过双链RNA(dsRNA)分子在mRNA水平上诱导特异性序列基因沉默的过程。随着对RNAi研究的不断深入,其作用机制的逐步阐明,RNAi技术也日趋完善和成熟,作为一种新型研究工具已广泛应用于医学领域中,尤其在恶性肿瘤的研究中作用显著,有望成为攻克肿瘤、病毒性疾病及遗传性疾病的新手段。现就RNAi技术应用于妇科肿瘤的研究与治疗进行综述。 RNA interference (RNAi) is a process that is widespread in plants and animals and induces specific sequence gene silencing at the mRNA level by double-stranded RNA (dsRNA) molecules. With the deepening of research on RNAi and the elucidation of its mechanism of action, RNAi technology is also increasingly sophisticated and mature. As a new research tool, it has been widely used in the field of medicine, especially in the study of malignant tumors and is expected to become Overcoming cancer, viral diseases and new means of genetic disease. Now on the application of RNAi technology in gynecologic oncology research and treatment are reviewed.