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对112例颈部肿块≥4cm的鼻咽癌患者进行随机对照试验，56例采用放疗加顺铂和5－FU（实验组），56例单纯放疗（对照组）。两组放疗方法相同。结果显示实验组和对照组鼻咽肿瘤残存率、颈结残存率相仿，分别为12．5％、62．5％和14．3％、57．1％。随诊1～6年，实验组远处转移为25．0％，对照组为46．4％。1年、3年、5年生存率实验组分别为92.9％、73．0％和56．8％，对照组分别为92.9％、49.7％和30.8％。远处转移率和生存率比较均有显著性差异，而局部复发率无显著差异。
A randomized controlled trial was conducted in 112 patients with nasopharyngeal carcinoma ≥4 cm in neck mass. Fifty-six patients were treated with radiotherapy plus cisplatin and 5-FU (experimental group) and 56 patients with radiotherapy alone (control group). The same two methods of radiotherapy. The results showed that the residual rate of nasopharyngeal tumors and the cervical residual rate in the experimental group and the control group were 12.5%, 62.5% and 14.3%, 57.1% respectively. After 1 to 6 years of follow-up, the distant metastasis was 25.0% in the experimental group and 46.4% in the control group. The 1-year, 3-year and 5-year survival rates were 92.9%, 73.0% and 56.8% in the experimental group and 92.9%, 49.7% and 30.8% in the control group respectively. Distant metastasis and survival rates were significantly different, while the local recurrence rate was no significant difference.