甲氰咪胍(Cimetieline)系H_2—受体阻断剂,广泛用于消化性溃疡、胃酸分泌增多症及上消化道出血的治疗。该药疗效可靠,但有一些副作用,而且涉及面较广,应引起临床医务工作者重视,现概叙如下。消化系统消化系统的副作用为轻度恶心,食欲减退。国外报道1例甲氰味胍所致肝炎,经电镜观察及肝活检:光学显微镜示汇管区呈以单核细胞为主的炎症浸润,偶见中性白细胞及嗜酸白细胞伴肝细胞灶性坏死。有些损伤的肝细胞内含有棕色颗粒,部分用Hell法胆汁染色阳性,未发现胆栓,许多肝细胞呈胆汁潴留,表现为空泡。线粒体和其它细胞未见异常,无胆栓。停 Cimetieline is a H 2 -receptor blocker that is widely used in the treatment of peptic ulcer, hypersecretion of gastric acid and upper gastrointestinal bleeding. The drug efficacy is reliable, but there are some side effects, but also involves a wide range, should cause clinical medical workers attention, are summarized below. Side effects of the digestive system digestive system mild nausea, loss of appetite. Foreign reports 1 case of cyanuric guanidine-induced hepatitis, electron microscopy and liver biopsy: optical microscopy showed a mononuclear cell-based inflammatory infiltration, and occasionally neutrophils and eosinophils with hepatocellular focal necrosis . Some of the damaged hepatocytes contained brown granules, some of them were stained positive with Hell bile, and no gallbladder was found. Many of the hepatocytes showed bile retention with vacuolization. No abnormal mitochondria and other cells, no gallbladder. stop