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The process of B cell development in the bone marrow occurs by the stepwise rearrangements of the V,D,and Jsegments of the Ig H and L chain gene loci.During early B cell genesis,productive IgH chain generearrangement leads to assembly of the pre-B cell receptor(pre-BCR),which acts as an important checkpointat the pro-B/preB transitional stage.The pre-BCR,transiently expressed by developing precursor B cells,comprises the Ig μH chain,surrogate light(SL)chains VpreB and λ5,as well as the signal-transducing hetero-dimer Igα/Igβ.Signaling through the pre-BCR regulates allelic exclusion at the Ig H locus,stimulates cellproliferation,and induces differentiation to small post-mitotic pre-B cells that further undergo therearrangement of the IgL chain genes.Recent advances in elucidating the key roles of pre-BCR in B celldevelopment have provided a better understanding of normal B lymphopoiesis and its dysregulated stateleading to B cell neoplasia.Cellular & Molecular Immunology.2004;1(2):89-94.
The process of B cell development in the bone marrow occurs by the stepwise rearrangements of the V, D, and Jsegments of the Ig H and L chain gene loci. Early early B cell genesis, productive IgH chain generearrangement leads to assembly of the pre- B cell receptor (pre-BCR), which acts as an important checkpointat the pro-B / preB transitional stage.The pre-BCR, transiently expressed by developing precursor B cells, comprises the Ig μH chain, surrogate light (SL) chains VpreB and λ5, as well as the signal-transducing hetero-dimer Igα / Igβ. Signaling through the pre-BCR regulates allelic exclusion at the Ig H locus, stimulates cellproliferation, and induces differentiation to small post-mitotic pre-B cells that further undergo therearrangement of the IgL chain genes.Recent advances in elucidating the key roles of pre-BCR in B cell development have provided a better understanding of normal B lymphopoiesis and its dysregulated state leading to B cell neoplasia. Cellular & Molecular Immunology. 2004; 1 (2) :8 9-94.