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Yushu Ms7.1 earthquake occurred on the Ganzi-Yushu fault zone,across which we carried out a joint relative-gravity and seismic-reflection survey,and then performed a gravity inversion constrained by the seismic-reflection result.Based on the data of complete Bouguer gravity anomaly and seismic reflection,we obtained a layered interface structure in deep crust down to Moho.Our study showed that the inversion could reveal the interfaces of strata along the survey profile and the directions of regional faults in two-dimension.From the characteristics of the observed topography of the Moho basement,we tentatively confirmed that the uplift of eastern edge of Qinghai-Tibet plateau was caused by the subduction of the Indian plate.