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目的:了解妊娠期高血压疾病(HDCP)患者的肾功能各项指标出现的变化及其在HDCP诊断治疗过程中的临床意义。方法:对146例HDCP患者(实验组)肾功能的多项指标进行检测,并用同期体检健康的孕产妇120例(对照组)作对照,分别检测两组的血清肌酐(Cr)、尿素氮(BUN)与尿酸(UA)水平。结果:实验组的Cr、BUN、UA水平均比对照组高,且比较均有显著性差异(P<0.05或P<0.01)。实验组和对照组的Cr水平的频数分布比较无显著性差异(P>0.05);而血清BUN与UA水平的频数分布比较有显著性差异(P<0.05或P<0.01)。不同程度HDCP患者之间Cr、BUN、UA水平的比较均有显著性差异(P<0.05或P<0.01)。结论:HDCP患者有不同程度的肾功能损害,表现为Cr、BUN、UA水平的升高,病情越重肾功能损害越显著,因此临床中应重视对HDCP患者肾功能的测定。
Objective: To understand the changes of various indexes of renal function in patients with HDCP and its clinical significance in the diagnosis and treatment of HDCP. Methods: A total of 146 patients with HDCP (experimental group) were enrolled in this study. A total of 120 healthy pregnant women (control group) were enrolled in this study. Serum creatinine (Cr), blood urea nitrogen BUN) and uric acid (UA) levels. Results: The levels of Cr, BUN and UA in the experimental group were higher than those in the control group, and the differences were significant (P <0.05 or P <0.01). There was no significant difference in the frequency distribution of Cr between experimental group and control group (P> 0.05). The frequency distribution of serum BUN and UA had significant difference (P <0.05 or P <0.01). The levels of Cr, BUN and UA in patients with HDCP were significantly different (P <0.05 or P <0.01). Conclusion: HDCP patients have different degrees of renal dysfunction, manifested as elevated levels of Cr, BUN and UA. The more severe the disease is, the more obvious the renal damage is. Therefore, the determination of renal function in HDCP patients should be emphasized in clinic.