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我们设计了一系列新型S-DABOs类目标化合物7a-f,通过简单有效的方法合成了该系列化合物,并进行了逆转录酶活性检测,发现该类化合物具有较好的生物活性,其中化合物7d的IC_(50)值达到了3.64μmol/L,是Nevirapine的IC_(50)值的1/2。
We designed a series of new target compounds 7a-f of S-DABOs and synthesized these compounds in a simple and effective way. The reverse transcriptase activity assay was carried out to find out that this compound has good biological activity. Compound 7d The IC 50 value reached 3.64 μmol / L, which is 1/2 of the IC 50 value of Nevirapine.