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目的研究细胞因子IGF-1在先天性肥厚性幽门狭窄中的表达。方法应用RT-PCR方法,对16例先天性肥厚性幽门狭窄病例的幽门肌组织及相对应的胃壁肌肉组织的IGF-1mRNA表达水平进行半定量检测。结果幽门肌组织中IGF-1mRNA的水平为0.6858±0.1639,高于胃壁肌肉组织的0.4063±0.0935,差别有统计学意义(P<0.001)。结论先天性肥厚性幽门狭窄患儿幽门肌中IGF-1mRNA表达增加,可能在幽门肌肥厚的过程中起了一定的作用。
Objective To study the expression of cytokine IGF-1 in congenital hypertrophic pyloric stenosis. Methods RT-PCR was used to detect the expression of IGF-1mRNA in pyloric muscle tissues and corresponding gastric muscle tissues of 16 patients with congenital hypertrophic pyloric stenosis. Results The level of IGF-1 mRNA in pyloric muscle tissue was 0.6858 ± 0.1639, which was higher than that in gastric muscle tissue (0.4063 ± 0.0935), with statistical significance (P <0.001). Conclusion The expression of IGF-1mRNA in pyloric muscle of children with congenital hypertrophic pyloric stenosis increased, which may play a role in the process of pyloric hypertrophy.