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目的:对瘢痕疙瘩的国际研究现状和趋势进行文献计量和可视化分析。方法:通过《Web of Science》数据库核心合集检索2000—2020年关于瘢痕疙瘩研究的文献。利用文献计量学方法对每年发表文献篇数、期刊和第1作者、国家与研究机构、研究领域、累计发表文献每年的被引频次、高被引文献、关键词进行统计分析。使用CiteSpace V软件对关键词进行可视化聚类；使用VOS-viewer软件对文题和摘要中的关键词语进行可视化聚类，分析研究方向和发展趋势。结果:共检索到2 693篇瘢痕疙瘩相关文献。2000—2020年，每年发表瘢痕疙瘩相关文献数量呈现出明显上升的趋势。共有777本期刊发表过瘢痕疙瘩相关文献，其中《Dermatologic Surgery》发表最多。以第1作者发表瘢痕疙瘩相关文献数量最多的是Rei Ogawa，其共发表52篇相关文献。共有98个国家进行了瘢痕疙瘩相关研究，发表相关文献数量最多的国家是美国（613篇），其次是中国（524篇）和日本（107篇）。共有2 656个机构进行了瘢痕疙瘩相关研究，发表相关文献数量最多的机构是中国上海交通大学（67篇）。根据《Web of Science》数据库学科分类，被纳入的文献涉及110个研究领域，排名前3者为皮肤科、外科、药物的研究和实验。纳入的文献总被引频次达47 746次，累计发表文献被引频次逐年增加，被引频次最高的文献（152次）发表于2011年。纳入文献中共有45 571个关键词，排名前5的关键词按照涉及文献数量从高到低排列分别是瘢痕疙瘩（588篇）、增生性瘢痕（385篇）、表达（198篇）、成纤维细胞（155篇）以及瘢痕（133篇）。利用CiteSpaceV软件进行可视化的关键词图谱进一步直观显示，研究侧重瘢痕疙瘩的成因、表现及其组成。VOS-viewer软件分析显示，瘢痕疙瘩的研究方向分为临床瘢痕疙瘩管理与瘢痕疙瘩机制研究这两大类；研究热点初期主要是从个案中探索瘢痕疙瘩的诊断和治疗，偏向表观研究，后期则侧重于瘢痕疙瘩统筹管理，其中机制研究深入到分子水平。结论:目前国际上关于瘢痕疙瘩的研究兴趣呈现出上升趋势，国外（美国等）和国内的研究机构都在对瘢痕疙瘩进行深入探索，以皮肤科为首，研究趋势逐渐由表观研究转向分子研究。“,”Objective:To conduct a bibliometric and visual analysis of the current status and trends of international research on keloids.Methods:The articles on keloid research from 2000 to 2020 in the core collection of n Web of Science database were retrieved. The bibliometrics method was applied to analyze the number of articles published per year, journals and first authors, countries and research institutions, research fields, the annual citation frequency of cumulative published articles, highly cited articles, keywords. CiteSpace V software was applied to visually cluster keywords, while VOS-viewer software was applied to visually cluster keywords in titles and abstracts in order to analyze research directions and development trends.n Results:A total of 2 693 keloid-related articles were retrieved. From 2000 to 2020, the number of keloid-related articles published every year showed a significant upward trend. Totally 777 journals published keloid-related articles, of which “Dermatologic Surgery” published the most. Rei Ogawa published the largest number of keloid-related articles as the first author, who published 52 related articles. A total of 98 countries conducted keloid-related research, of which the United States was the country with the largest number of related articles published (613 articles), followed by China (524 articles) and Japan (107 articles). A total of 2 656 institutions conducted keloid-related research, and the institution with the largest number of related articles published was Shanghai Jiao Tong University of China (67 articles). According to the subject classification of the n Web of Science database, the included articles involved 110 research fields, and the top three were dermatology, surgery, and medicine, research and experimental. The included articles were cited 47 746 times in total, and the citation frequency of cumulative published articles increased by year. The most frequently cited article (152 times) was published in 2011. There were a total of 45 571 keywords in the included literature. The top 5 keywords ranked according to the number of articles involved from high to low were keloid (588 articles), hypertrophic scar (385 articles), expression (198 articles), fibroblast (155 articles), and scar (133 articles). The keyword map visualized by CiteSpaceV software further displayed that the research focused on the cause, performance, and composition of keloids. VOS-viewer software analysis showed that the research direction of keloids was divided into two categories of clinical keloid management and keloid mechanism research; the initial research hotspots were mainly to explore the diagnosis and treatment of keloids from individual cases, with a preference for apparent research; in the later stage, the focus was on the overall management of keloids, in which the mechanism research went to the molecular level.n Conclusions:At present, international research interest on keloids is showing an upward trend. Both foreign (the United States, etc.) and domestic research institutions are conducting in-depth explorations of keloids. With dermatology as the leader, the research trend is gradually shifting from apparent research to molecular research.