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目的对坐浴一号洗液进行抗炎镇痛药效作用研究,以期为该制剂治疗肛瘘术后创面愈合的临床疗效提供现代药理学实验依据。方法采用二甲苯致小鼠耳廓肿胀炎症模型和醋酸致小鼠扭体疼痛模型,以金玄痔科熏洗散中成药制剂为阳性药物对照,分为高、中、低剂量组观察坐浴一号的抗炎和镇痛药理作用。结果坐浴一号与阳性药物组比较,其低剂量组无显著性差异,但中剂量组和高剂量组均有显著性差异,优于阳性药物组。结论坐浴一号洗液具有明显的抗炎和镇痛作用。
OBJECTIVE To study the anti-inflammatory and analgesic efficacy of BATH-1 bath lotion in order to provide a modern pharmacological basis for the clinical efficacy of this preparation in the treatment of wound healing after anal fistula surgery. Methods Xylene-induced mouse auricle swelling and inflammation model and acetic acid-induced writhing pain model in Jin Xuan Hemorrhoid Washing Powder proprietary Chinese medicine as a positive drug control, divided into high, medium and low dose group observation bath One of the anti-inflammatory and analgesic pharmacological effects. Results Compared with the positive drug group, there was no significant difference in the low dose group. However, there was significant difference between the middle dose group and the high dose group, which was better than the positive drug group. Conclusion Bath 1 lotion has obvious anti-inflammatory and analgesic effects.