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目的:评价甲基强的松龙冲击疗法辅助抗病毒药物对重症病毒性脑炎患儿的疗效及其对脑神经功能的影响。方法:选取医院2015年1月—2016年12月期间收治的重症病毒性脑炎患儿90例,将其随机分为观察组与对照组(每组45例);对照组患者给予盐酸纳洛酮、神经节苷脂、喜炎平注射液等常规治疗,观察组患者在对照组基础上加用甲基强的松龙冲击疗法治疗,评价两组患者治疗后的总有效率和神经功能指标如血清S100B蛋白、神经元特异性烯醇化酶(Neuron-specific enolase,简称NSE)、髓磷脂碱性蛋白(Myelin basic protein,简称MBP)和神经生长因子(Nerve growth factor,简称NGF)测得值的变化情况。结果:观察组患者治疗后的总有效率高于对照组(P<0.05),S100B蛋白、NSE、MBP和NGF指标测得值均低于对照组(P<0.05)。结论:甲基强的松龙冲击疗法辅助抗病毒药物对重症病毒性脑炎患儿的临床疗效优于常规疗法,有助于改善患儿脑神经功能。
Objective: To evaluate the effect of methylprednisolone impact therapy adjuvant antiviral drug on children with severe viral encephalitis and its effect on neurological function. Methods: Ninety children with severe viral encephalitis who were hospitalized from January 2015 to December 2016 in our hospital were randomly divided into observation group and control group (45 cases in each group). Patients in control group were given naloxone hydrochloride Ketones, ganglioside, Xiyanping injection and other conventional treatment, the observation group patients in the control group based on the use of methylprednisolone impact therapy to evaluate the two groups of patients after treatment, total effective rate and neurological function indicators Such as serum S100B protein, neuron-specific enolase (NSE), Myelin basic protein (MBP) and nerve growth factor (NGF) Changes in the situation. Results: The total effective rate of the observation group was higher than that of the control group (P <0.05). The measured values of S100B protein, NSE, MBP and NGF were lower than those of the control group (P <0.05). Conclusion: The effect of methylprednisolone impact therapy adjuvant antiviral drug is better than that of conventional therapy in children with severe viral encephalitis, which is helpful to improve the neurological function in children.