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现在有一种新的热潮,即对慢性气道阻塞病人联合使用口服茶碱和供吸入用的B_2兴奋剂以达到较好的支气管扩张的效果,甚至还加用了溴化异丙托品和大剂量的局部类固醇。对这种昂贵的合用多种药物的价值应仔细考虑。茶碱已使用多年,但其支气管扩张效果如何尚不清楚。关于磷酸二酯酶抑制剂的早期结论未必可信,至少说在治疗量下血浆浓度为10～20mg/l时是如此,同样,关于细胞内钙转移或腺苷受体或前列腺素的拮抗作用的结论也是如此。哮喘病人口服茶碱可加强吸入β_2兴奋
Now there is a new craze for the use of oral theophylline and inhalation of B 2 stimulants in patients with chronic airway obstruction to achieve better bronchodilator effects and even with the use of ipratropium bromide and The dose of topical steroid. The value of this expensive combination of multiple drugs should be carefully considered. Theophylline has been used for years, but its bronchiectasis is unclear. Early conclusions about phosphodiesterase inhibitors are not necessarily reliable, at least for the plasma concentration of 10-20 mg / l at the therapeutic level, as well as for intracellular calcium transfer or adenosine receptor or prostaglandin antagonism The same is true. Ophthalmic patients with oral theophylline can enhance the inhalation of beta 2 excitement