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目的研究不同碘氟摄入量人群甲状腺结节和TPOAb阳性的检出率。方法对山东巨野县的适碘低氟、高碘低氟和高碘高氟3个农村地区共396名23岁以上居民进行甲状腺B超检查、TPOAb和尿碘测定。结果适碘低氟组、高碘低氟组和高碘高氟组尿碘中位数(MUI)分别为207.1、383.9和461.7μg/L;甲状腺结节检出率16.5%、22.0%和11.5%,TPOAb阳性率25.9%、33.7%和12.4%。高碘高氟组人群甲状腺结节检出率明显低于高碘低氟组人群(P<0.05)。各组人群随着年龄的增大,甲状腺结节检出率增高,60岁以上最高,分别为24.4%、29.2%和18.8%,经趋势性卡方检验有显著意义(P<0.05)。高碘高氟组甲状腺B超正常人群TPOAb阳性率明显低于适碘低氟组和高碘低氟组。结论在水碘200~300μg/L范围内,若水氟自(0.99±0.29)mg/L升至(1.67±0.19)mg/L,无论是甲状腺结节检出率还是TPOAb阳性率均明显降低。
Objective To study the positive detection rate of thyroid nodules and TPOAb in patients with different iodine fluoride intake. Methods A total of 396 residents over the age of 23 in three rural areas in Juye County of Shandong Province, including iodine-deficient fluoride, iodine-depleted iodine and iodine-enriched iodine, were tested for thyroid B ultrasound, TPOAb and urinary iodine. Results The median urinary iodine (MUI) of the iodine-poor group, the iodine-poor group and the high-iodine group were 207.1, 383.9 and 461.7 μg / L, respectively. The detection rates of thyroid nodules were 16.5%, 22.0% and 11.5 %, TPOAb positive rate of 25.9%, 33.7% and 12.4%. The detection rate of thyroid nodules in high iodine and high fluoride group was significantly lower than that in high iodine and low fluoride group (P <0.05). The detection rate of thyroid nodules was increased in all groups with age, the highest was over 60 years old, which was 24.4%, 29.2% and 18.8% respectively. The trend chi-square test was significant (P <0.05). The positive rate of TPOAb in high-iodine high-fluorine group thyroid B-normal population was significantly lower than that in the low-fluorine group and high-iodine-poor group. Conclusions In the range of 200-300 μg / L of water iodine, the detection rate of thyroid nodules or the positive rate of TPOAb decreased significantly when the fluoride content increased from (0.99 ± 0.29) mg / L to (1.67 ± 0.19) mg / L.