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目的探讨色素性微囊肾嫌色细胞癌的临床病理特点、诊断及鉴别诊断。方法对1例色素性微囊肾嫌色细胞癌的临床资料、组织学形态及免疫组化结果进行分析,并复习相关文献。结果肿瘤界限清楚,无明显包膜;切面灰白、灰黄至棕黄色。镜下瘤细胞排列呈微囊及腺样结构,可见色素沉着,肿瘤间质内可见钙化灶。免疫组化:瘤细胞CAM2.5、AE1/AE3、CK7、EMA、E-cadherin和CD117(+),S-100、HMB45和vimentin(-)。结论色素性微囊肾嫌色细胞癌是一种少见的肿瘤,最重要的特征是具有相对良性的生物学行为,远处转移很少见。
Objective To investigate the clinicopathological features, diagnosis and differential diagnosis of chromophobe microcellocytic renal cell carcinoma. Methods The clinical data, histological morphology and immunohistochemical results of 1 pigmented chromophobe renal cell carcinoma were analyzed and relevant literatures were reviewed. Results clear tumor boundaries, no significant envelope; cut gray, yellowish brown to yellowish brown. Microscopic tumor cells arranged in microcapsules and adenoid structures, showing pigmentation, visible within the tumor interstitial calcification. Immunohistochemistry: tumor cells CAM2.5, AE1 / AE3, CK7, EMA, E-cadherin and CD117 (+), S-100, HMB45 and vimentin (-). Conclusion Pigmented microcapsular renal cell carcinoma is a rare tumor, the most important feature is a relatively benign biological behavior, distant metastasis is rare.